ICEC 0942
CAS No. 1805833-75-3
ICEC 0942 ( ICEC0942;CT7001 )
Catalog No. M12761 CAS No. 1805833-75-3
ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
|
50MG | 1782 | Get Quote |
|
100MG | 2250 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameICEC 0942
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NoteResearch use only, not for human use.
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Brief DescriptionICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM)
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DescriptionICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM);displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9; demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM; shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.Solid Tumors Phase 1 Clinical
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SynonymsICEC0942;CT7001
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1805833-75-3
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Formula Weight394.52
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Molecular FormulaC22H30N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCC4CCNCC4O
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Chemical Name(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2.Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.
2.Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.
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